DSP Development Scientist

Job Description

Downstream Process Scientist



An opportunity has become available for a self-motivated and communicative Downstream Process Development Scientist to join the Bioprocessing Development Unit at an Antibody Manufacturing site near Oxford. This team oversees process improvement of Raw Materials Manufacturing processes.



  • Improving existing and/or developing new techniques for purification of antibodies and their introduction into manufacturing
  • Writing and maintaining SOPs in addition to the training of staff in their implementation
  • Investigation, via Design of Experiments into new analytical methods for determining antibody quality and their introduction into manufacturing
  • Supporting the Business Custom Manufacturing Offerings


  • Minimum BSc in a Science, preferably including modules dealing with topics such as protein-protein interactions.
  • 2 years post-graduation experience in an industrial protein purification setting or MRes or PhD of similar focus.
  • Working knowledge of chromatography systems such as AKTA, NGC etc.
  • Proven understanding of the concepts behind protein purification by chromatography
  • Comfortable communicating and discussing ideas in a mixed group of various scientific backgrounds
  • Knowledge of Design of Experiments and associated software such as Minitab, MODDE or JMP
  • Working knowledge of antibody generation via any biological system
  • Working Knowledge of implementing Quality by Design
  • Experience of working to ISO9001 standards Experience applying Lean Six Sigma in an industrial laboratory setting